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In addition to the full-fledged cognitive tests (e.g., MMSE, ADAS), various information processing paradigms, derived from event-related potentials (ERPs), are suggested for the diagnosis of dementia disorders. While there is no established time frame for the application of these paradigms, usually it is assumed that the paradigms should be applied at least 6 months prior to the diagnosis of Alzheimer’s disease (AD). This work aims at a better understanding of the application and time frame of various ERP paradigms for the diagnosis of AD. The source space analysis revealed that all ERP paradigms used in the study were elicited from broad areas of the scalp with only a few channels showing significant differences between the AD and the control group. The most reliable channel set for AD diagnosis within the study period (within about a year prior to the diagnosis of AD) was the extended space algorithm (ESA) source-space analysis, the sensitivity for this set was more than 0.83 (AD vs. CTRL). The data of this study suggest that the ERA and ESA paradigms may be useful for the diagnosis of AD prior to 12 months and approximately 1 year, respectively, prior to its diagnosis.Removal of high-level metallo-beta-lactamase-1 in a burn unit: description of a strategy and analysis of cost-effectiveness.
Antimicrobial stewardship (AMS) programs are a cornerstone of effective infection control. In the burn unit at Hadassah University Hospital, Jerusalem, Israel, one of the most important AMS interventions was the removal of high-level metallo-beta-lactamase-1 (MBL-1) infected patients from the burn unit. To describe a multi-step strategy that included AMS team consultation, initial therapy with a Cefepime loading dose and a 22-gauge catheter to draw blood samples for phenotypic testing, and then readministration of appropriate antibiotics once MBL-1-producing Enterobacteriaceae (EPE) were
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