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The last two decades have witnessed an enormous increase in research on the human brain and its endocrinology. There has been a breakthrough in the understanding of the neuronal circuits and neuropeptides involved in hunger and satiety, which has initiated the effort to develop specific peptide-based therapies. However, the control of food intake and energy homeostasis in the brain is largely hormone dependent. The identification of leptin as a signal for satiety, the understanding of the hypothalamic neuronal mechanisms controlling energy homeostasis, and the recognition of how specific peptides from the CNS control appetite were followed by a surge in discovery of neuropeptides and neuromodulatory pathways in the brain. This review will focus on the key roles of two major gastrointestinal peptides, ghrelin and GLP-1, in the CNS regulation of food intake, and on the implication of leptin in neuroendocrine disorders..”
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