FULL Geometer’s Sketchpad 4.07
We have copied the Geometer’s Sketchpad. The FULL version, by contrast, already contains this functionality.Dimerization of myosin motor domain through the SH3-like domain interferes with intramolecular allosteric interactions among the three domains (tail, neck, and head).
The myosin motor domain dimerizes in solution, which makes its working mechanism less understood. To evaluate the effect of this dimerization on the working mechanism of the myosin motor domain, we tested its dimerization with the SH3-like domain in solution and analyzed the functional changes of the motor domain. The myosin motor domain was observed to form dimers with a stoichiometric ratio of 1:1 in solution at submicromolar concentrations, without formation of larger oligomers. The dimerized motor domain shifted the actin-activated ATPase activity to lower the temperature optimum, whereas it did not change the sensitivity to Ca2+. On the other hand, the SH3-like domain functionally modulated the subcellular localization and mechanochemistry of the motor domain. The dimerized motor domain seemed to bind to the SH3-like domain in its SH3-like domain-binding domain more strongly in the presence of actin than in its absence, whereas the SH3-like domain hardly bound to the motor domain in the absence of actin. These data showed that the myosin motor domain could interact with the SH3-like domain in solution, and this interaction could influence its working mechanism.A Wisconsin Republican state lawmaker facing a recall election later this month has come under fire for a Facebook post last week in which she compared police brutality against minorities to “straight up genocide” against Indigenous people.
Jennifer Shilling, a state representative from La Crosse, wrote that “your squad car’s lights and sirens” going past “the home of a non-white criminal suspect,” could serve “as a warning to other non-whites to think twice before committing a crime.”
“You may feel a little bad for the criminal suspect,” she said. “But think about the future where you are sitting in that home years from now — with no job, no home, and family in poverty.”
“Your squad car’s lights and sirens … saved you from a life of crime,” she continued. “But
https://colab.research.google.com/drive/1Zk79GfkrRY4GPQhh6MBfYukxFoUGnws8
https://colab.research.google.com/drive/1NO1qBHHj_WH9n7kFXtJPuuoJLsumpAvp
https://colab.research.google.com/drive/1vR6z_F-6MdKs3AQf0E9vJ-HpmVQOZYbO
https://colab.research.google.com/drive/11A-lh347dDGVN7LLK5GcX1ohL5THYsZZ
https://colab.research.google.com/drive/1tRw9Ea_9S3cQrSqTLErHocijtDgjdNw9
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