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. · Saving the data to the database and structure database on how to write the files in SQL database.Members of the Jak-STAT signalling pathway in trypanosomes.
Genetic analysis of trypanosomatids has revealed a remarkably conserved signalling pathway that is essential for cell growth and differentiation. An essential function of this signalling pathway is to regulate gene expression by means of signal recognition and transduction. This review summarizes the knowledge on the Jak-STAT (signal transducers and activators of transcription) signalling pathway in trypanosomes, with a focus on the proteins that are involved in tyrosine phosphorylation and protein-protein interactions. The trypanosome genome contains homologues of many proteins involved in the Jak-STAT signalling pathway including the members of the mammalian STAT protein family, the SOCS protein family and a putative homologue of the tyrosine kinase JAK1. The functional analysis of conserved components of this signalling pathway will help to improve our knowledge of the basic biological process of trypanosome differentiation and parasite-host interactions.Influence of prophylactic antibiotics on the surgical outcome of patients with primary open-angle glaucoma and cataracts.
To evaluate the effect of the preoperative administration of intraocular prophylactic antibiotics on the outcome of surgical treatment of patients with primary open-angle glaucoma (POAG) and cataracts. Outcome measures included the intraoperative and postoperative success rates and postoperative complications. Univariate and multivariate analyses were performed to evaluate the effect of preoperative antibiotics on various patient characteristics, including a history of previous ocular surgery. The Kaplan-Meier method was used to estimate the cumulative success rates. One hundred thirty-six consecutive patients (132 eyes) with POAG and cataracts were enrolled in the study. In 74 patients (61%), no antibiotics were given preoperatively; in 44 patients (36%), ceftazidime (0.5%) was administered before surgery and in 14 patients (11%) vancomycin (0.6%) was instilled. Among the 44 patients (36%) who received preoperative ceftazidime, the postoperative cumulative success rate was 88.0% at 1 year and 79.2% at 2 years; for the 14 patients (11%) who received vancomycin, the rate was 82.9% at 1 year and 78.6% at 2 years (P
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