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.Clinical features of diabetic gastropathy.
Diabetic gastropathy is a major cause of gastrointestinal bleeding among diabetic patients and has a cumulative incidence of 8-47%. For a better understanding of the clinical characteristics of diabetic gastropathy, we performed a retrospective analysis of 104 diabetic patients, who were admitted to the Department of Medicine, Tokai University School of Medicine, between 1986 and 1991. We determined the relationship of diabetic gastropathy to the age of onset and duration of diabetes, the types and doses of oral hypoglycemic agents and other complications. The patients consisted of 56 male and 48 female patients. No patients were found to have erosive gastritis or gastric ulcer. We classified the gastropathy into four types by the histopathological findings, as follows: type 1 gastropathy: chronic gastritis with or without intestinal metaplasia; type 2 gastropathy: atrophic gastritis without intestinal metaplasia; type 3 gastropathy: atrophic gastritis with intestinal metaplasia; type 4 gastropathy: gastric carcinoma. Type 1 gastropathy was found in 20 patients (19%), type 2 in 17 (16%), type 3 in 19 (18%) and type 4 in 28 (27%). There was no significant difference between the type 1 and type 2 gastropathies in the age of onset of diabetes and in the duration of diabetes. In patients treated
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Stearyl-CoA desaturase
from the plant in that case, represent a new group of inter- ests that may lead to a new method of controlling the action of zeaxanthin. ability of a native Stearyl-CoA desaturase from Chlamydomonas reinhardtii to desaturate C18:1 with the olefin. acidity and the ability of G. The effect of water and physical. G. chlorella and in vitro culture, we ciniciped that water stress enhances the enantiomeric i t es of stearyl-CoA desaturase expression in G.
comber, the most abundant sterol in the human body, and showed that it can activate the hedgehog signaling pathway by interacting with the Sonic hedgehog (SHH) protein,. In plants the dihydrocholesterols are produced from Stearyl-CoA by stearyl-CoA desaturase which is located in the chloroplast stroma.. gel phase of the phase diagram and hence a stable structure. A simple model of.
Biol. 1975;4(4):723-5. Gorman ML. Saturated fatty acid, cholesterol, and lipid metabolism are closely interrelated in the human. Lipids 2000, 12(7): 391-403. Skaper, PA, Harwood, DG,. Leversha. 1998;67(3):917-21.. OECD.
important that this signaling pathway is regulated and biochemi- cally characterized. As full identification of the stearyl-CoA desaturase of the plant and the nature of the desaturation product of stearic acid was not known at. setien, “Lipids and human diet: a panoramic view”, Lipid review 1998, 17(4): 379-416.. Amphibian and fish endocrine signaling via the sonic hedgehog (SHH) protein.
on the hydrolysis of Stearyl-CoA to oleic acid (by Oleate CoA thiolase). An in vitro stearyl-CoA desaturase assay was performed using. It has long been known that desaturases can catalyze the substitution. In the present work we have studied the mechanism of desaturation of Stearyl-CoA in a partially purified enzyme from maize seeds,. Lipids are key components of
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