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Chronic stress is considered a risk factor for the development of schizoaffective disorder (SAD), a severe mood disorder. The mesial temporal lobe (MTL) is an integral node of the stress-hypersensitive neural network and plays a key role in emotional and memory processes. We hypothesized a resting-state functional connectivity (rs-FC) deficit in the MTL in SAD. Seed-based rs-FC analyses were conducted in 22 SAD patients and 23 controls, using the mesial temporal cortex and the dorsal anterior cingulate cortex (dACC) as seed regions. Patients with SAD showed a right-sided mesial temporal rs-FC deficit, that was strongly related to a right amygdala activation pattern and a decreased mesial temporal-subcortical connectivity. Normalization of the rs-FC deficit by a MTL focal hyperconnectivity (defined by a seed-to-whole brain connectivity analysis) improved classification performance between SAD and healthy controls. The present data indicate a right-sided MTL rs-FC deficit in SAD, that may be relevant to the alterations in limbic and subcortical brain regions found in SAD. rs-FC in the MTL may serve as a biomarker in SAD.
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Oct 21, 2017 · Download Windows 10 Enterprise and LTSB Free 90-day Trial. Windows 10 Enterprise LTSC, version 1809 (Updated Sept 2018) MSDN ISO Ä°SO’lar Ä°ngilizce.. releases a new OEM version of Windows 10 Redstone 5 (RS5) worldwide. Latest Windows 10 Pro ISO Is Now Available. Download Latest Windows 10 ISO [Active/Visible] I have all free Windows 10 RS5 iso’s, Microsoft has released Windows 10 RS5 (build 1809) on September 4, 2018. Latest Windows 10 Pro ISO Is Now Available.
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