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Yttrium-90 (^90^Y) is a beta-emitting radioisotope with an average half-life of 64.1 hours, which, when combined with a selective bone-seeking agent, can be used to treat bone metastases. Radioembolization consists of the delivery of the ^90^Y-labeled microspheres to the vascular territories of the metastases, which may include not only the fed vasculature but also the neovasculature found in the metastases. In the past, the ^90^Y-labeled microspheres (BSM) were labeled with the β-emitter ^188^Re, but the toxicity of ^188^Re was not always negligible, and the activity of ^188^Re varies considerably, depending on the source.

^90^Y-glass-sealed microspheres (^90^Y-GSM), on the other hand, have recently been developed in an attempt to improve the clinical efficacy of radioembolization.

^90^Y-GSM are glass microspheres sealed with a glass cover and contain ^90^Y in a crystal lattice. The use of a cover prevents the penetration of the radioisotope into the microspheres, increasing the activity and thus the efficacy. They also have a high ^90^Y content (up to 25%) and are radiolucent. The microspheres are coated with a nonabsorbable polyester which allows for a time-release of ^90^Y, increasing their therapeutic effect.[@b1-imcrj-9-075],[@b2-imcrj-9-075]

To our knowledge, the only published studies regarding ^90^Y-GSM are small case series, thus the data on its safety and efficacy are still scarce.

Herein, we report a case of a 78-year-old male who developed an ischemic stroke following transcatheter ^90^Y radioembolization with ^90^Y-GSM.

Case report
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The patient was admitted to the emergency room (ER) for a transient ischemic attack of the left arm. He had been diagnosed with a large right psoas

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.Monday, November 24, 2011

David Gilmour’s Mirror Man

By Ian Macdonald

Well, it’s that time of year again. The annual Penguin (pronounced “Pengend”), the glorious publication of the BBC Written Archives Centre. According to Macdonald, “it seems utterly unlikely that the BBC would be able to produce a book which contained all the interviews they conducted as well as those of their own staff: once, had there been an ‘open door policy’ in the BBC, it is unlikely that door would have closed on it.”

As he so eloquently points out, “I wrote my first Penguin in 1990, and, although I have learned much from the experience, I was still uneasy about a book with so much of my personal life exposed.” Fortunately, Ian Macdonald’s approach was always one of balance, breadth and impartiality. He has done a very good job in offering the readers the material in an accessible manner, without concealing the truth.

From the beginning of the project, Ian has done a great deal of research into the archives and also researched the relevant material that has been compiled in the book and found a great deal of interest and enjoyment in the results. When you hold the book in your hands, you feel the pleasure of taking part in the journey of a very worthwhile project. He has written a biography of one of the UK’s greatest songwriters and musicians, David Gilmour.

You are met with the first real surprise when you open the book. That is because the very first entry is actually a letter from the late Floyd Ezard. Ezard was David Gilmour’s personal assistant and although he did not know all that he has divulged, he has offered the very best advice to Ian as the biography progressed.

As we are a family-run bookshop, in addition to the use of the WAC, we are permitted to lend and sell these books. There are no copyright or publishing restrictions. Hence, in addition to ordering this book in all bookshops and online booksellers (from Amazon to Waterstone’s), we should also have copies available in our shop.

There is a BBC TV show on BBC4 tonight about the Beatles that will introduce readers to the man who supported them and helped them to survive the transition from the psychedelic Beatles of the 1960s to the more mundane face of the 1970s.

The book is a round-up of all the interviews that David Gil

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