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The relationships between metabolic stability and palliative therapy have been studied, and a previous study showed a higher rate of failure of chemotherapy with a greater number of metastatic sites, including those in the liver, bone, brain, and lymph nodes \[[@CR9]\]. Vincristine and doxorubicin are considered to have a high rate of metabolic instability, and the failure of palliative chemotherapy may be associated with limited treatment options; therefore, palliative therapy is likely to result in a loss of efficacy \[[@CR12]\]. Although the rate of metabolic stability with bortezomib is relatively high, the treatment regimen does not appear to be associated with treatment outcomes, including response and survival.
Recently, new regimens of bortezomib-containing therapy in relapsed/refractory MM have been studied \[[@CR6], [@CR11], [@CR16]\]. In a previous study, bortezomib-containing regimens were compared with conventional therapy, in which the majority of the patients in the conventional therapy group received only single-agent chemotherapy. The study compared outcomes in these patients, revealing that the bortezomib-based regimens were associated with higher rates of
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