WiPer is a Java-based application that uses a statistical permutation test in order to easily detect inter-connected genes in co-expression networks.
WiPer is capable of handling large networks, of over 1000 genes and run more than 1000 permutations. The larger the network, the more time it takes to run the analysis and generate the results.
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Gene-gene co-expression network analysis and gene-gene interaction network analysis has been an area of active research for decades. Newer mathematical approaches for gene-gene interaction networks analysis, such as network methods, e.g., based on microarrays data or using information from ChIP on chip data, have been recently developed. These approaches, in combination with genomics tools and gene expression data, can yield gene-gene interaction networks as opposed to gene-gene co-expression networks.
With the advent of high-throughput genomics technologies such as microarrays and ChIP on chip analysis, and other sequencing techniques, we are approaching the era of having vast amounts of genomics data on almost any type of biological organism. Therefore, the goal of constructing gene-gene interaction networks from genomics data may become feasible. However, the challenge is that it is a time consuming and tedious process. Once a gene-gene interaction network is constructed, it is still difficult to find connections between different network components. It can be very difficult to visualize the gene-gene interaction network in a small piece of biological knowledge, such as a paper. The gene-gene interaction network can be used to analyze inter-connected components of a biological knowledge and to make conclusions about those components. As such, it is essential to have a tool that helps visualize gene-gene interaction networks in a paper.
WiPer Download With Full Crack (Wireless Interaction Permutation Test) is a Java-based application that utilizes the permutation test to detect connections between genes in gene-gene interaction networks. The permutation test is a nonparametric statistical test that is suitable for detecting connections between different sets of objects. Permutation testing is used in various fields including genetics, statistics and medical research.
WiPer is capable of analyzing networks of 1000 genes and run more than 1000 permutations. The larger the network, the more time it takes to analyze the network and generate the results. The main drawback of WiPer is that it is slow when analyzing large networks. The large networks can be obtained either from microarray data or from ChIP on chip data.
WiPer Description:
Gene-gene co-expression network analysis and gene-gene interaction network analysis has been an area of active research for decades. Newer mathematical approaches for gene-gene interaction networks analysis, such as network methods, e.g., based on microarrays data or using information from ChIP on chip data,
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WiPer is a Java-based application that uses a statistical permutation test in order to easily detect inter-connected genes in co-expression networks.
WiPer is capable of handling large networks, of over 1000 genes and run more than 1000 permutations. The larger the network, the more time it takes to run the analysis and generate the results.
The graphical output of the analysis is a simple graph composed of different nodes, connected by different edges.
In addition to the graphical view, the application also provides a table of top significant gene interactions and a table of top significant groups of genes.
MetaCore™ is a versatile software platform for the analysis of gene and protein interaction networks, including cellular signaling and transcription.
MetaCore™ is especially suited for modeling interactions between individual proteins, protein complexes, and genetic interactions.
It also enables the construction of regulatory networks, utilizing available experimental knowledge on transcription factors, their target genes, and the involved protein modifications.
MetaCore™ also includes tools for the analysis of protein sequence features, such as secondary structure prediction, protein-protein interactions, and protein modifications.
The aim of this study was to demonstrate the validity of concurrent intestinal recovery by analyzing the relationships between bowel movements, straining and gas.
Eighty-seven patients with slow transit constipation participated in this study.
Measurements were made before and after a defecatory training period.
Bowel movements were defined as those without sensation of incomplete evacuation.
Stool straining was defined as the need for assistance in defecation or digital rectal massage.
Gas was defined as the sensation of rectal fullness and bloating.
The defecatory training program consisted of:
– 4 to 8 weeks
– 2 to 3 times per week
– 2 to 3 sets of five to six slow and relaxed contractions (duration: 3 to 5 minutes)
– Total 20 to 40 minutes
A significant association was found between the number of bowel movements and straining and gas on day 0 of the study, before and after defecatory training.
The straining and gas scores decreased after defecatory training.
The number of bowel movements increased after defecatory training and the difference was significant on days 8 and 29.
Changes in bowel movements were positively associated with straining and gas on the same days.
The straining and gas scores decreased on day 8, and the number of bowel movements increased on day 29.
A significant association was found between the number of
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WiPer is an intuitive Java-based application that was developed to detect if two genes are linked or not, if there is a statistical evidence supporting such a relationship. We can use WiPer in order to:
– analyze co-expression networks
– check new co-expression relationships
– detect new edges in the network
– detect modules
WiPer helps to visualize the interactions among genes or the connections between genes and their regulators, which can be used to perform complex comparative studies to identify genes related to specific biological processes.
WiPer is a stand-alone application, but it is capable of handling large networks, of over 1000 genes and run more than 1000 permutations. The larger the network, the more time it takes to run the analysis and generate the results.
Used/calculated values for gene networks:
We calculate for every gene in the network the number of genes it is linked to, to find out which gene are the most connected. We also calculate the number of genes that are linked to a given gene (referred to as ‘hub genes’).
Used/calculated values for module networks:
We calculate for every module (k-clique) in the network the number of genes that it contains. We also calculate the number of genes that are linked to a given module.
Used/calculated values for regulator networks:
We calculate for every transcription factor in the network the number of genes it regulates, the number of genes that are regulated by a given transcription factor and the number of genes that are regulated by a given transcription factor.
Network visualization
We create a visualization of the network with the following tools:
– node size – based on the number of co-expression links, i.e. node size = (connections number).
– node color – based on the correlation value, i.e. node color = (correlation value).
– node border width – based on the number of co-expression links, i.e. node border width = (connections number).
We can also filter the visualization by using the filter tool by:
– node color – based on the correlation value, i.e. node color = (correlation value).
– node border width – based on the number of co-expression links, i.e. node border width = (connections number).
Similar to co-expression networks, we can also display the most connected genes, the modules, the transcription factors, the most connected
What’s New in the?
WiPer is a Java application that runs in a Java Runtime Environment (JRE).
It requires Java version 1.5 or later to run.
WiPer allows users to perform a statistical permutation test on gene expression data.
WiPer requires data in the tab-delimited text format (a “CSV” file) to be provided as input.
WiPer outputs a simple output file containing the significant test results that are ranked by a false discovery rate (FDR) value.
The FDR value is calculated using the obtained test results.
The FDR value is the probability that any of the detected significant test results are false.
The program also allows the user to generate a background permutation test to assess the significance of results.
WiPer Features:
The user can choose to run a single test, or multiple tests on a single dataset.
The user can choose the number of permutations.
The user can choose to randomize the samples within each group, or randomly permute the samples among all groups (also known as “global permutation”).
The output file contains the statistical values and a graphical view of the data that can be saved to an image file for further analysis.
The output file can be viewed and saved in a variety of formats, including as a.txt,.csv or.pdf file.
The output file can be saved to a folder of choice.
The size of the network is only limited by the size of your computer’s RAM.
In case you have a very large dataset, WiPer offers the option to split the network into smaller networks, for a more efficient run.
The size of the networks is only limited by the size of your computer’s RAM.
WiPer FAQs:
Can WiPer handle datasets with thousands of samples?
Yes. WiPer supports very large networks. WiPer supports networks of thousands of genes in thousands of samples. You can run a single test, or run multiple tests on a single dataset. The user can also choose the number of permutations, which can be as large as you want. WiPer has been tested successfully with datasets that contain more than 1000 genes and up to 100,000 samples.
WiPer returns the number of permutations and the size of the network that are tested.
The false discovery rate (FDR) value is calculated by dividing the number of false detections by the number of detected ones.
The power of WiPer is equivalent to a t-test.
A t-test is a test of significance using a normal distribution to approximate the distribution of results, followed by a Bonferroni correction for multiple testing.
WiPer can also be used to calculate p-values in place of FDR.
In this case, the test results are inversely ranked.
In other words, the significance value associated with the first test result is the largest
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System Requirements:
Minimum:
OS: XP, Vista, Windows 7, Windows 8, Windows 8.1 (32-bit only)
Processor: Intel Core i3 2GHz or AMD Athlon x4 2GHz
Memory: 1GB
Graphics: AMD Radeon HD 5450 or Nvidia GeForce GTS 450
Hard Disk: 2GB of free space
Additional Notes:
Launch Laptop-Mode-Tools and click OK on the message box that appears.
Step 4. Click Apply and then OK on the message box that appears.
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